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August 1, 1989Proceedings of the National Academy of SciencesOpen Access

Translation of glucose-regulated protein 78/immunoglobulin heavy-chain binding protein mRNA is increased in poliovirus-infected cells at a time when cap-dependent translation of cellular mRNAs is inhibited.

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Population

Poliovirus-infected cells

Design

Preclinical

Authors

PSPeter SarnowStanford University

Discussion

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Implication

Cellular findings do not guide poliovirus care; leaves open cap-independent translation of stress mRNAs in human infection.

Structured PICO

P
Population
Poliovirus-infected cells
I
Intervention
Poliovirus infection
O
Outcome
Translation rate of glucose-regulated protein 78/immunoglobulin heavy-chain binding protein mRNA

Demonstrates that glucose-regulated protein 78/immunoglobulin heavy-chain binding protein mRNA can be translated via a cap-independent initiation process during poliovirus infection.

Cite This Study

Peter Sarnow (1989) studied this question.

synapsesocial.com/papers/6a825d4bedb9ea86fc3acc5ehttps://doi.org/10.1073/pnas.86.15.5795
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Capped mRNAs with Reduced Secondary Structure Can Function in Extracts from Poliovirus-Infected Cells1982 · 65 citations
  2. 2Poliovirus mutant that contains a cold-sensitive defect in viral RNA synthesis1988 · 48 citations
  3. 3Proteolysis of the p220 component of the cap-binding protein complex is not sufficient for complete inhibition of host cell protein synthesis after poliovirus infection1987 · 114 citations
  4. 4The adenovirus tripartite leader may eliminate the requirement for cap-binding protein complex during translation initiation1988 · 107 citations
  5. 5Poliovirus mutant that does not selectively inhibit host cell protein synthesis.1985 · 160 citations