Population
Adenovirus tripartite leader-containing mRNAs and poliovirus-infected cells
Comparison
Adenovirus tripartite leader vs mRNAs without the tripartite leader
Design
Preclinical
Authors
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Hypothesis-generating for cap-independent viral translation; leaves open extension to pathogenesis or antiviral targets.
The adenovirus tripartite leader enables mRNA translation initiation without requiring an intact cap-binding protein complex, explaining the preferential translation of viral late mRNAs.
Dolph et al. (1988) studied this question.
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