Population
in vivo model using transfected plasmids
Design
Preclinical
Authors
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Hypothesis-generating for eIF-4F-independent adenovirus translation; leaves open validation in human models before any therapeutic consideration.
The adenovirus tripartite leader facilitates translation independent of eIF-4F through an unstructured conformation rather than internal ribosome binding.
Dolph et al. (1990) studied this question.
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