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June 15, 1996Genes & DevelopmentOpen Access

Selective translation initiation by ribosome jumping in adenovirus-infected and heat-shocked cells.

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Population

Adenovirus-infected and heat-shocked mammalian cells

Comparison

Adenovirus infection or heat shock (stress) vs Normal conditions (abundant eIF-4F)

Design

Preclinical

Authors

AYAndrew YuehNational Health Research InstitutesRSRobert J. SchneiderUniversity of Münster

Discussion

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Implication

Enables late adenovirus translation during eIF-4F inactivation; leaves open applicability to other viruses or cellular mRNAs.

Structured PICO

P
Population
Adenovirus-infected and heat-shocked mammalian cells
I
Intervention
Adenovirus infection or heat shock (stress)
C
Comparator
Normal conditions (abundant eIF-4F)
O
Outcome
Translation initiation mechanism (ribosome jumping vs linear scanning)

Adenovirus late mRNAs use a ribosome jumping mechanism to initiate protein synthesis when eIF-4F is inactivated, such as during late infection or heat shock.

Cite This Study

Yueh et al. (1996) studied this question.

synapsesocial.com/papers/6a73a3051aa2fc9e78fb6d3ehttps://doi.org/10.1101/gad.10.12.1557
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of mutations downstream of the internal ribosome entry site on initiation of poliovirus protein synthesis1994 · 52 citations
  2. 2The adenovirus tripartite leader may eliminate the requirement for cap-binding protein complex during translation initiation1988 · 107 citations
  3. 3Adenovirus inhibition of cellular protein synthesis is prevented by the drug 2-aminopurine.1990 · 58 citations
  4. 4Influence of 5' proximal secondary structure on the translational efficiency of eukaryotic mRNAs and on their interaction with initiation factors.1986 · 150 citations
  5. 5Cell proteins bind to multiple sites within the 5' untranslated region of poliovirus RNA.1989 · 115 citations