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September 1, 1990Proceedings of the National Academy of SciencesOpen Access

Adenovirus inhibition of cellular protein synthesis is prevented by the drug 2-aminopurine.

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Population

Cells infected with adenovirus

Comparison

2-aminopurine vs Untreated adenovirus-infected cells

Design

Preclinical

Authors

JHJ T HuangNew York UniversityRSRobert J. SchneiderUniversity of Münster

Discussion

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Implication

Hypothesis-generating for translation-targeted antivirals; leaves open roles of additional initiation factors in viral host shut-off.

Structured PICO

P
Population
Cells infected with adenovirus
I
Intervention
2-aminopurine
C
Comparator
Untreated adenovirus-infected cells
O
Outcome
Prevention of suppression of cellular protein synthesissurrogate

2-aminopurine prevents adenovirus-induced shut-off of host cellular protein synthesis despite the activation of DAI kinase and phosphorylation of eIF-2 alpha, suggesting other initiation factors are involved in viral translation inhibition.

Cite This Study

Huang et al. (1990) studied this question.

synapsesocial.com/papers/6a8aa06fd513dfc69d721e1fhttps://doi.org/10.1073/pnas.87.18.7115
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Inhibition of translation in cells infected with a poliovirus 2Apro mutant correlates with phosphorylation of the alpha subunit of eucaryotic initiation factor 21989 · 82 citations
  2. 2Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.1980 · 8,376 citations
  3. 3Interferon Induction by Viruses. XVI. 2-Aminopurine Blocks Selectively and Reversibly an Early Stage in Interferon Induction1988 · 80 citations
  4. 4Gene induction by interferons and double-stranded RNA: selective inhibition by 2-aminopurine.1988 · 119 citations
  5. 52-Aminopurine Selectively Inhibits the Induction of β-Interferon, c- fos , and c- myc Gene Expression1988 · 231 citations