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May 1, 1987Journal of Biological ChemistryOpen Access

Adenovirus late protein synthesis is resistant to the inhibition of translation induced by poliovirus.

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Population

Cells infected with adenovirus and superinfected with poliovirus

Design

Preclinical

Authors

JCJ.L. CastrilloConsejo Superior de Investigaciones CientíficasLCLuis CarrascoThe Honourable Society of Lincoln's Inn

Discussion

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Implication

Differential resistance may shape viral co-infection outcomes; leaves open leader-independent mechanisms in translational control.

Structured PICO

P
Population
Cells infected with adenovirus and superinfected with poliovirus
I
Intervention
Poliovirus superinfection and/or 3-methyl quercetin
O
Outcome
Synthesis of adenovirus late proteins (e.g., hexon, fiber)surrogate

Adenovirus late mRNAs exhibit differential resistance to poliovirus-induced translational shut-off despite sharing a common 5' leader sequence.

Cite This Study

Castrillo et al. (1987) studied this question.

synapsesocial.com/papers/6a8a7d65d88561daf2cc1441https://doi.org/10.1016/s0021-9258(18)48240-3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Protein Synthesis in HeLa Cells Double-infected with Encephalomyocarditis Virus and Poliovirus1982 · 12 citations
  2. 2Reversion by hypotonic medium of the shutoff of protein synthesis induced by encephalomyocarditis virus1981 · 45 citations
  3. 3Poliovirus mutant that does not selectively inhibit host cell protein synthesis.1985 · 160 citations
  4. 4Poliovirus protease 3C (P3-7c) does not cleave P220 of the eucaryotic mRNA cap-binding protein complex1985 · 28 citations
  5. 5Alterations in initiation factor activity from poliovirus-infected HeLa cells.1979 · 59 citations