Plasma Homocysteine Is Weakly Correlated with Plasma Endothelin and von Willebrand Factor but not with Endothelium-dependent Vasodilatation in Healthy Postmenopausal Women
Why the study?
Is increased fasting plasma homocysteine associated with impaired endothelial function in healthy postmenopausal women?
Population
63 hysterectomized but otherwise healthy postmenopausal women, mean age 54.8 +/- 3.5 years
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for homocysteine-endothelial links in postmenopausal women; prospective studies needed before any clinical consideration.
Structured PICO
Is increased fasting plasma homocysteine associated with impaired endothelial function in healthy postmenopausal women?
P
Population
63 hysterectomized but otherwise healthy postmenopausal women, mean age 54.8 +/- 3.5 years
I
Intervention
Fasting total plasma homocysteine (tHcy) levels (observational exposure)
O
Outcome
Endothelial function assessed by plasma concentrations of endothelin (ET), von Willebrand factor (vWF), plasminogen activator inhibitor type 1 (PAI-1), and brachial artery flow-mediated, endothelium-dependent vasodilatation (FMD)surrogate
Increased fasting homocysteine in postmenopausal women is weakly correlated with some plasma markers of endothelial dysfunction (ET and vWF) but not with flow-mediated vasodilatation.
Cite This Study
Roo et al. (1999) studied this question.