Population
Xenopus oocytes expressing human ether-à-go-go-related gene K(+) channel (HERG) constructs
Comparison
C-terminal deletion constructs of HERG vs Wild-type HERG or other deletion constructs
Design
Preclinical
Authors
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HERG C-terminal residues regulate channel function; hypothesis-generating for arrhythmia mechanisms, no clinical implications yet.
Residues within the C-terminus of the HERG channel are essential for channel expression and regulate gating, with deactivation likely mediated by interaction with the N-terminus.
Aydar et al. (2001) studied this question.
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