Why the study?
Bovine kobuvirus has been detected in 13 countries across four continents since its identification in 2003, suggesting widespread distribution.
Bovine kobuvirus is globally widespread and may be a causative agent for neonatal calf diarrhoea, though further pathogenicity studies are required.
BKV may warrant inclusion in neonatal calf diarrhoea differentials; leaves open its causal role pending targeted studies.
Bovine kobuvirus (BKV) is a single-stranded, positive sense, non-enveloped RNA virus in genus Kobuvirus of family Picornavirus. BKV was first identified in the culture media of HeLa cell containing calf serum in 2003. Since then, BKV has been detected in 13 countries of four different continents, suggesting widespread in the world. Herein, we review the detection and genomic characterization of BKV in 13 countries. All studies tested bovine faecal samples for BKV. These studies provide evidence that BKV might be a causative agent for neonatal calf diarrhoea. Therefore, further efforts including animal challenge study are urgently needed to unveil the pathogenicity of BKV.
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Hao et al. (2020) studied this question.
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