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November 28, 2013Thrombosis and Haemostasis

The comparison of thrombocytosis and platelet-lymphocyte ratio as potential prognostic markers in colorectal cancer

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Why the study?

Does elevated preoperative platelet count or platelet-lymphocyte ratio predict worse survival in patients with colorectal cancer and hepatic metastasis?

Population

454 patients, comprising 336 with colorectal cancer (CRC) and 118 with hepatic metastasis of CRC (mCRC)

Design

Cohort

Follow-up

10 years (retrospective data collection period)

Authors

MKMarcin KrzystanekVJValéria JósaKDKristóf Dede

Discussion

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Overview

May aid preoperative risk stratification in CRC; Level 3 data leaves open clinical adoption pending prospective validation.

Structured PICO

Does elevated preoperative platelet count or platelet-lymphocyte ratio predict worse survival in patients with colorectal cancer and hepatic metastasis?

P
Population
454 patients, comprising 336 with colorectal cancer (CRC) and 118 with hepatic metastasis of CRC (mCRC)
I
Intervention
Elevated preoperative platelet count and platelet-lymphocyte ratio (PLR)
O
Outcome
Overall survival (OS) and Disease-free survival (DFS)hard clinical

Elevated preoperative platelet count, but not platelet-lymphocyte ratio, serves as an independent prognostic marker for worse survival in patients with colorectal cancer and its hepatic metastases.

Cite This Study

Krzystanek et al. (2013) studied this question.

synapsesocial.com/papers/6a82633a004fcf503374af09https://doi.org/10.1160/th13-08-0632
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Also Consider

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  1. 1Platelets Release Thrombopoietin (Tpo) upon Activation: another Regulatory Loop in Thrombocytopoiesis?2000 · 79 citations
  2. 2Platelet alpha-granule proteins: studies on release and subcellular localization1979 · 452 citations
  3. 3Global Cancer Statistics, 20022005 · 18,399 citations
  4. 4Clinical significance of preoperative neutrophil-lymphocyte versus platelet-lymphocyte ratio in patients with operable colorectal cancer2012 · 414 citations
  5. 5Type beta transforming growth factor in human platelets: release during platelet degranulation and action on vascular smooth muscle cells.1986 · 544 citations