In vitro study reveals tricuspion A inhibits nitric oxide production in microglial cells, suggesting potential as a lead compound for neuroinflammatory diseases.
One new labdane diterpenoid, tricuspion A (1), as well as five known triterpenoids (2–6) were isolated from Salvia tricuspis Franch (family Labiatae). The structure of tricuspion A was identified by extensive spectroscopic analysis and by comparison with previously reported data. Compounds 1–6 were evaluated for their inhibitory effects on the NO production in LPS-stimulated BV-2 microglia cells, and 1 exhibited potent inhibitory activity with IC50 value of 14.92 ± 0.51 μM. Compound 1 might exert anti-neuroinflammatory activity through inhibiting the excessive production of NO and down-regulating the protein expression of iNOS and COX-2. As such, labdane diterpenoid (tricuspion A) could provide promising anti-neuroinflammatory lead compound for further structural modification.
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Xie et al. (2023) studied this question.
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