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June 1, 1993AJP Heart and Circulatory Physiology

Role of cation gradients in hypercontracture of myocytes during simulated ischemia and reperfusion

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Population

Adult rat ventricular myocytes

Comparison

Alteration of transsarcolemmal proton, Na+, and… vs Simulated ischemia and reperfusion with normal…

Design

Preclinical

Authors

MNMasashi NishidaKyoto first Red Cross hospitalSBS. BorzakBrigham and Women's HospitalBKBernd KraemerSpitäler Schaffhausen

Discussion

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Implication

Reducing Na+/Ca2+ entry avoids reperfusion Ca2+ overload and hypercontracture in rat myocytes; hypothesis-generating for exchanger-targeted strategies.

Structured PICO

P
Population
Adult rat ventricular myocytes
I
Intervention
Alteration of transsarcolemmal proton, Na+, and Ca2+ gradients to reduce Na+ entry via Na(+)-H+ exchange and Ca2+ entry via Ca(2+)-Na+ exchange
C
Comparator
Simulated ischemia and reperfusion with normal buffer (unaltered gradients)
O
Outcome
Hypercontracture of myocytes and intracellular Ca2+ concentration ([Ca2+]i) at reperfusionsurrogate

Na+ and Ca2+ entry via Na+-H+ and Na+-Ca2+ exchangers contribute to intracellular Ca2+ overload and hypercontracture during reperfusion in adult rat ventricular myocytes.

Cite This Study

Nishida et al. (1993) studied this question.

synapsesocial.com/papers/6a826b7afe5ce613f33acfd0https://doi.org/10.1152/ajpheart.1993.264.6.h1896
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Contracture of isolated rat heart cells on anaerobic to aerobic transition1982 · 55 citations
  2. 2Passive electrical properties, mechanical activity, and extracellular potassium in arterially perfused and ischemic rabbit ventricular muscle. Effects of calcium entry blockade or hypocalcemia.1990 · 105 citations
  3. 3Excitation-contraction coupling in postischemic myocardium. Does failure of activator Ca2+ transients underlie stunning?1990 · 201 citations
  4. 4The mechanism of early contractile failure of isolated rat ventricular myocytes subjected to complete metabolic inhibition.1989 · 130 citations
  5. 5Hysteresis and the length dependence of calcium sensitivity in chemically skinned rat cardiac muscle.1988 · 65 citations