Key result
Prolonged simulated ischemia increased the susceptibility of rat cardiomyocytes to hypercontracture, occurring at significantly lower cytosolic Ca2+ levels than normoxic cells (0.80 vs 1.27 mumol/L; P<0.01).
Why the study?
Does simulated ischemia increase the susceptibility of rat cardiomyocytes to hypercontracture?
Population
Rat cardiomyocytes
Comparison
Simulated ischemia followed by 20 minutes of… vs Normoxic cells
Design
Preclinical
Authors
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No immediate clinical implications; hypothesis-generating for protein dephosphorylation as a target in reperfusion injury.
Does simulated ischemia increase the susceptibility of rat cardiomyocytes to hypercontracture?
Absolute Event Rate: 0.8% vs 1.27%
p-value: p=< .01
Prolonged simulated ischemia increases the susceptibility of rat cardiomyocytes to hypercontracture, a mechanism that appears to be driven by protein dephosphorylation.
Ladilov et al. (1997) studied Simulated ischemia. Simulated ischemia vs. Normoxic cells was evaluated on Cytosolic Ca2+ concentration at which cells developed maximal hypercontracture (Camax) (p=< .01). Prolonged simulated ischemia increased the susceptibility of rat cardiomyocytes to hypercontracture, occurring at significantly lower cytosolic Ca2+ levels than normoxic cells (0.80 vs 1.27 mumol/L; P<0.01).
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