March 1, 1959Journal of HygieneOpen Access

The influence of the age of the host on local virus multiplication and on the resistance to virus infections

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Population

Mice of different ages

Design

Preclinical

Authors

AMAnne McLarenLifeArc FSF. K. SandersSouth Carolina Department of Natural Resources

Discussion

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Implication

Age-dependent resistance in mice warrants no clinical changes in viral management; leaves open human translation for enteroviral myocarditis.

Structured PICO

Population

Mice of different ages

Intervention

Inoculation with EMC virus (intramuscular, intraperitoneal, oral) or Coxsackie virus Texas and Connecticut-5 strains (intracerebral, intramuscular)

Outcome

Susceptibility to virus infection and virus multiplication in muscle and brainsurrogate

Host age inversely correlates with susceptibility to EMC and Coxsackie virus infections in mice, likely due to decreased viral accessibility to host cells.

Cite This Study

McLaren et al. (1959) studied this question.

synapsesocial.com/papers/6a82787f004fcf503374b13f https://doi.org/10.1017/s0022172400019938

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Implication

Age-dependent resistance in mice warrants no clinical changes in viral management; leaves open human translation for enteroviral myocarditis.

The influence of the age of the host on local virus multiplication and on the resistance to virus infections

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The influence of the age of the host on local virus multiplication and on the resistance to virus infections

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider