Why the study?
Does exposure to a cold environment worsen Coxsackie virus infection in adult mice?
Population
Adult mice infected with the Conn. 5 strain of Coxsackie virus
Comparison
Exposure to a cold environment (4°C) vs Suckling mice at 25°C
Design
Preclinical
Authors
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Cold exposure may worsen murine Coxsackie outcomes; hypothesis-generating with no implications for human practice.
Does exposure to a cold environment worsen Coxsackie virus infection in adult mice?
Continuous exposure to cold transforms a non-lethal Coxsackie virus infection into a uniformly fatal one in adult mice.
Boring et al. (1956) studied this question.
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