What question did this study set out to answer?

To investigate the effect of cortisone on susceptibility to lethal Coxsackie virus infection in adult mice.

May 1, 1951Experimental Biology and Medicine

Lethal Infection with Coxsackie Virus of Adult Mice Given Cortisone

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Population

Adult mice

Comparison

Cortisone administration prior to Coxsackie… vs Adult mice not given cortisone

Design

Preclinical

Authors

EKE. D. KilbourneTulane University FHFrank L. HorsfallRivers State University

Discussion

Member takes

Implication

Cautions against extrapolating cortisone effects to human viral infections; leaves open utility of this mouse model for virologic studies.

Key Points

To investigate the effect of cortisone on susceptibility to lethal Coxsackie virus infection in adult mice.
Administered cortisone to adult mice prior to infection with Coxsackie virus.
Demonstrated virus multiplication, serial passage, and specific neutralization in infected mice.
Recovered Coxsackie virus from a human source using the adult mice model.
Adult mice given cortisone were lethally infected with the normally insusceptible Coxsackie virus.
Multiplication of Coxsackie virus was confirmed through serial passage in treated mice.
Specific neutralization of the virus was achieved, allowing for recovery from a human source.

Structured PICO

Population

Adult mice

Intervention

Cortisone administration prior to Coxsackie virus infection

Comparator

Adult mice not given cortisone (ordinarily insusceptible)

Outcome

Lethal infection and viral multiplication

Cortisone administration renders adult mice susceptible to lethal Coxsackie virus infection, providing a viable animal model for viral study and recovery.

Cite This Study

Kilbourne et al. (1951) studied this question.

synapsesocial.com/papers/6a74cb7d1078cf7de2b1db79 https://doi.org/10.3181/00379727-77-18702

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Implication

Cautions against extrapolating cortisone effects to human viral infections; leaves open utility of this mouse model for virologic studies.

Lethal Infection with Coxsackie Virus of Adult Mice Given Cortisone

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Lethal Infection with Coxsackie Virus of Adult Mice Given Cortisone

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider