Key result
Cold exposure decreases Coxsackie virus resistance in mice while elevated temperatures markedly inhibit viral multiplication.
Population
Adult mice infected with the Conn.-5 strain of Coxsackie virus
Design
Preclinical
Authors
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Temperature effects on viral resistance in mice are hypothesis-generating; leaves open relevance to human Coxsackie infections.
Elevated environmental temperature suppresses Coxsackie virus multiplication in adult mice, whereas cold exposure reduces resistance, an effect not solely mediated by adrenocortical hypersecretion.
Walker et al. (1958) studied Coxsackie virus infection. Environmental temperature alteration (4°C or 36°C) and ACTH was evaluated on Resistance to viral infection and viral multiplication. Exposure to a 4°C environment decreased resistance to Coxsackie virus in adult mice, while a 36°C environment markedly inhibited viral invasion and multiplication.
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