What question did this study set out to answer?

To determine how acute and chronic cold exposure affect brown adipose tissue morphology and the pathogenesis of coxsackievirus B in mice.

September 1, 1970Canadian Journal of Microbiology

Changes in brown adipose tissues and coxsackievirus B pathogenesis in mice on acute and chronic cold exposure

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Population

Adult female mice

Comparison

Acute or chronic cold exposure combined with… vs Normal room temperature

Design

Preclinical

Authors

EGE. Irene GrodumsUniversity of Saskatchewan GDG. DempsterUniversity of Toronto

Discussion

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Implication

These murine findings are hypothesis-generating; clinical relevance to human viral myocarditis remains undetermined.

Key Points

To determine how acute and chronic cold exposure affect brown adipose tissue morphology and the pathogenesis of coxsackievirus B in mice.
Adult female mice were exposed to acute or chronic cold conditions and inoculated with coxsackievirus B-3 or B-2.
Mice were either maintained in the cold or returned to room temperature post-infection to assess tissue damage in brown fat, heart, and brain.
Viral persistence and infectious titers recovered from heart and brain tissues were tracked following prolonged cold exposure.
Coxsackievirus B-3 damage in brown adipose tissue was most severe when mice were infected during acute cold and returned to room temperature, whereas cold acclimation restricted damage to localized lesions.
Myocardial injury was aggravated exclusively in mice kept continuously in the cold post-inoculation, which also produced higher and longer-persisting viral titers in heart and brain tissues.
Cold exposure caused no clear alterations in brain pathogenesis and failed to alter the age-dependent resistance of mice to coxsackievirus B-2.

Structured PICO

Population

Adult female mice

Intervention

Acute or chronic cold exposure combined with coxsackievirus B-3 or B-2 inoculation

Comparator

Normal room temperature

Outcome

Viral damage in brown adipose tissues, myocardium, and brain, and infectious virus amount recoveredsurrogate

Ambient temperature changes, specifically acute cold exposure, can significantly aggravate coxsackievirus B-3 induced myocardial and brown adipose tissue damage in mice.

Cite This Study

Grodums et al. (1970) studied this question.

synapsesocial.com/papers/6a947b97cff80aed1b3edb9c https://doi.org/10.1139/m70-140

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Changes in brown adipose tissues and coxsackievirus B pathogenesis in mice on acute and chronic cold exposure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Changes in brown adipose tissues and coxsackievirus B pathogenesis in mice on acute and chronic cold exposure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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