Key result
Higher early and late LV filling rates linked to larger LA size and MPA diameter.
Why the study?
It remained unclear whether interconnected cardiopulmonary changes can be simultaneously characterized using non-dedicated whole-body MRI in individuals free of overt cardiovascular disease.
Are MRI-derived left ventricular filling rates associated with left atrial and pulmonary artery dimensions in individuals without overt cardiovascular disease?
Cross-Sectional (n=339)
No
Are MRI-derived left ventricular filling rates associated with left atrial and pulmonary artery dimensions in individuals without overt cardiovascular disease?
Answers are grounded in this paper and cite their sources.
In individuals without overt cardiovascular disease, MRI-derived LV filling dynamics are associated with structural alterations of the left atrium and pulmonary vasculature, suggesting early subclinical changes across the cardiopulmonary axis can be detected by whole-body MRI.
Introduction Left ventricular diastolic dysfunction is associated with left atrial remodeling and alterations of the pulmonary circulation. However, whether these interconnected changes across the cardiopulmonar y axis can be simultaneously characterized using a non-dedicated whole-body MRI examination in individuals free of overt cardiovascular disease remains unclear. Methods 339 subjects (mean age 56.4 years; 43.4% female) without overt cardiovascular disease were included. Linear regression models, adjusted for age, sex, and cardiovascular risk factors, explored the association of Left ventricle (LV) filling rates with left atrium (LA) size and function, and mean pulmonary artery (MPA). Results Average maximal LA was 19.6 cm 2 , minimal LA 11.8 cm 2 , area-based LA function 39.8%, non-electrocardiogram-synchronized LA size 16.8 cm 2 , LV early filling rate 227.1 mL/s, late filling rate 238.4 mL/s, and MPA diameter 2.67 cm. Higher early and late LV filling rates were associated with larger maximal LA size across all models ( β = 2.30; β = 1.00), minimal LA size ( β = 1.41; β = 0.77), and non-electrocardiogram-synchronized LA size ( β = 1.86; β = 0.90, all p < 0.001, fully adjusted model). Higher early LV filling rates, but not higher late LV filling rates, were associated with larger MPA diameter across all models ( β = 0.06, p = 0.03, fully adjusted model). Conclusion In individuals free of overt cardiovascular disease, MRI-derived LV filling dynamics were associated with structural alterations of the left atrium and pulmonary vasculature, suggesting that changes across the cardiopulmonar y axis may already be detectable by whole-body MRI before clinical disease becomes apparent.
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Wintergerst et al. (2026) conducted a cross-sectional in Free of overt cardiovascular disease (n=339). Left ventricular early and late diastolic filling rates vs. Lower filling rates (continuous variable) was evaluated on Maximal left atrial (LA) size (β = 2.30, 95% CI 1.82-2.77, p=<0.001). Higher early and late left ventricular filling rates were significantly associated with larger left atrial size and main pulmonary artery diameter in individuals free of overt cardiovascular disease.
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