Key result
Larger maximum LA size links to lower MRI-derived total lung volume in participants without CVD.
Why the study?
Left atrial physiology and hemodynamics are intimately connected to cardiac and lung function, but the relationship between MRI-based left atrial size and function with MRI-based lung volume and pulmonary function testing parameters was uncharacterized in individuals without overt cardiovascular disease.
Does MRI-based lung volume correlate better with subclinical left atrial impairment than pulmonary function testing in individuals without overt cardiovascular disease?
Cross-Sectional (n=400)
No
Does MRI-based lung volume correlate better with subclinical left atrial impairment than pulmonary function testing in individuals without overt cardiovascular disease?
Effect estimate: β = -0.03 (95% CI -0.05 to -0.01)
p-value: p=0.006
MRI-based assessment of lung volume is inversely associated with left atrial size and function, suggesting it may offer greater sensitivity in detecting subclinical LA impairment than standard pulmonary function testing.
MRI lung volume inversely associated with LA size without CVD; leaves open whether it detects subclinical impairment better than PFT.
Left atrial (LA) physiology and hemodynamics are intimately connected to cardiac and lung function in health and disease. This study examined the relationship between MRI-based left atrial (LA) size and function with MRI-based lung volume and pulmonary function testing (PFT) parameters in the population-based KORA study cohort of 400 participants without overt cardiovascular disease. MRI quantification assessed LA size/function in sequences with and without ECG synchronization, alongside lung volume. Regression analysis explored the relationship of LA with MRI lung volume and PFT parameters. Among 378 participants (average age 56.3 ± 9.2 years; 42.3% women), non-gated LA size averaged 16.8 cm 2 , while maximal and minimal LA size from gated measurements were 19.6 cm 2 and 11.9 cm 2 respectively. The average MRI-derived lung volume was 4.0 L, with PFT showing a total lung capacity of 6.2 L, residual lung volume of 2.1 L, and forced vital capacity of 4.1 L. Multivariate regression analysis, adjusted for age, gender, and cardiovascular risk factors, revealed an inverse association between maximum LA size, non-gated LA, and LA area fraction with lung volume (ß = − 0.03, p = 0.006; ß = − 0.03, p = 0.021; ß = − 0.01, p = 0.012), with no significant association with PFT parameters. This suggests that MRI-based assessment may offer greater sensitivity in detecting subclinical LA impairment than PFT.
No takes yet. Share an insight, caveat, or question.
Wintergerst et al. (2024) conducted a cross-sectional in Without overt cardiovascular disease (n=400). MRI-based left atrial (LA) size and function assessment was evaluated on Association between maximum LA size (LAmax) and MRI-derived total lung volume (β = -0.03, 95% CI -0.05 to -0.01, p=0.006). Maximum left atrial size was inversely associated with MRI-derived total lung volume (β = -0.03) in participants without cardiovascular disease, but not with pulmonary function testing parameters.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: