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Prodromal angina may lose protective effect after post-MI remodelling; leaves open clinical relevance pending prospective validation.
rodromal angina occurring shortly before the onset of acute myocardial infarction (MI) has a cardioprotective effect in patients with acute MI by the mechanism of ischaemic preconditioning. 1 2 However, it has been reported that several conditions, including aging and diabetes mellitus, may abolish the beneficial effect of prodromal angina. 3 4 Recent experimental studies have reported that the cardioprotective mechanism of preconditioning is impaired by post-MI left ventricular (LV) remodelling. 5 Patients with prior MI have an increased risk of developing acute MI. Once acute MI has occurred, the prognosis is worse than that for patients without prior MI. This study was undertaken to investigate the influence of prior MI on the effect of prodromal angina in patients with acute MI.
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Masaharu Ishihara (2006) studied this question.
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