The prognostic value of AGTR1 A1166C gene polymorphism in all-cause mortality and heart failure in patients with acute myocardial infarction

Introduction The prognostic role of the AGTR1 A1166C genetic polymorphism in patients with acute myocardial infarction (AMI) is controversial and inconsistent across various study populations. Materials and Methods We conducted a cross-sectional analysis with 6 months of follow-up. All participants were identified for AGTR1 A1166C polymorphism using the polymerase chain reaction method, with follow-up on survival status at 6 months from the date of admission. The Cox regression model and survival curves were estimated using the Kaplan–Meier curve and corrected with confounding factors. Results The proportions of AA, AC and CC genotypes were 88.1%, 10.9%, and 1%, respectively. Mortality after 6 months occurred in 31 cases (30.7%). 6-month survival analysis through Kaplan-Meier curves showed a trend with lower cumulative survival of the AC and CC genotype group with p = 0.02, and the outcomes were still significant with p = 0.05 when corrected for confounding factors. Although Kaplan-Meier curves and Cox regression models indicated a marginally elevated incidence of heart failure within the AC and CC genotype populations following a six-month follow-up period, the statistical analysis revealed no significance. Conclusion AGTR1 A1166C gene polymorphisms could be an important factor in increasing all-cause mortality in patients after AMI.