Key result
The AGTR1 rs5186 polymorphism was significantly associated with an increased risk of restenosis after percutaneous coronary intervention (allelic OR 1.31; 95% CI 1.17-1.47; p<0.001).
Why the study?
Studies regarding the AGTR1 rs5186 polymorphism and restenosis after PCI had yielded controversial results.
Is the AGTR1 rs5186 polymorphism associated with an increased risk of restenosis after PCI?
Meta-Analysis (n=5,208)
Is the AGTR1 rs5186 polymorphism associated with an increased risk of restenosis after PCI?
Odds Ratio: 1.31 (95% CI 1.17–1.47)
p-value: p=<0.001
The AGTR1 rs5186 polymorphism is significantly associated with an increased risk of restenosis after PCI, particularly in Asian populations.
AGTR1 rs5186 may aid post-PCI restenosis risk stratification; leaves open prospective validation before clinical adoption.
Background: Progress has been made in genetic investigations on restenosis for the past 20 years, many studies regarding AGTR1 rs5186 polymorphism and restenosis after percutaneous coronary intervention (PCI) have been published, but the result remains controversial. The study aimed to explore the relationship between rs5186 polymorphism and the risk of restenosis after PCI. Methods: We performed a systematic search on PubMed, Web of Science, Embase, CNKI, and Wan Fang databases up to December 2021. Two authors individually extracted all useful data of each study involved in this meta-analysis and assessed the study quality using the Newcastle-Ottawa scale. Odds ratios (ORs) and 95% confidence intervals (CIs) were combined in different genetic models for evaluation using a random-effects model or fixed-effect model. Results: There were eventually 8 studies of 1111 cases and 4097 controls eligible for this meta-analysis. Significant associations were found between rs5186 polymorphism and restenosis after PCI.allelic (OR: 1.31, 95% CI: 1.17−1.47, p < 0.001), homozygous (OR: 1.90, 95% CI: 1.50−2.44, p < 0.001), heterozygous (OR: 1.10, 95% CI: 0.93−1.29, p = 0.27), recessive (OR: 1.80, 95% CI: 1.37−2.36, p < 0.001), dominant genetic model (OR: 1.24, 95% CI: 1.06−1.44, p = 0.006). Subgroup analyses indicated a significant association in Asians. Conclusions: The rs5186 polymorphism in the AGTR1 gene increases the risk of restenosis after PCI in Asians significantly.
No takes yet. Share an insight, caveat, or question.
Lv et al. (2022) conducted a meta-analysis in Restenosis after percutaneous coronary intervention (n=5,208). AGTR1 rs5186 polymorphism vs. Absence of polymorphism / Controls was evaluated on Restenosis after PCI (OR 1.31, 95% CI 1.17-1.47, p=<0.001). The AGTR1 rs5186 polymorphism was significantly associated with an increased risk of restenosis after percutaneous coronary intervention (allelic OR 1.31; 95% CI 1.17-1.47; p<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: