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ET-1 discovery launches vasoconstrictor pathway research; leaves open clinical translation of antagonists in hypertension.
c This is the original landmark report of the discovery of endothelin-1, including the isolation and sequencing of the peptide, identification of the gene sequence for its generation, and the pathway of production. This paper also highlights the vascular pharmacology and the pivotal role of ET-1 in vasoconstriction and hypertension.
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Teresa M. Attinà (2005) studied this question.
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