Answers are grounded in this paper and cite their sources.
[reaction: see text] CuH-catalyzed asymmetric conjugate reduction of beta-silyl-alpha,beta-unsaturated esters has been developed. Using PMHS as a stoichiometric source of hydride and in situ generated CuH ligated by Solvias' JOSIPHOS analogue PPF-P(t-Bu)(2) leads to highly enantioselective 1,4-reductions.
No takes yet. Share an insight, caveat, or question.
Lipshutz et al. (2006) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: