Why the study?
Diagnostic algorithms for suspected myocardial infarction are limited by requiring assay-specific hs-cTn cutoff concentrations and change criteria.
Does a common change criteria algorithm (3C) for hs-cTn provide comparable diagnostic performance for acute myocardial infarction compared to established ESC algorithms in patients with suspected MI?
Population
5011 emergency department patients with suspected MI and serial hs-cTn results
Comparison
Common change criteria (3C) algorithm vs ESC algorithms for rule in and rule out
Design
Two prospective cohort studies
Authors
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Supports 3C as assay-agnostic option with comparable accuracy to ESC; leaves open need for prospective validation before practice change.
Does a common change criteria algorithm (3C) for hs-cTn provide comparable diagnostic performance for acute myocardial infarction compared to established ESC algorithms in patients with suspected MI?
The 3C algorithm offers a uniform, assay-agnostic alternative to established ESC algorithms for diagnosing MI, with comparable diagnostic accuracy.
Pickering et al. (2025) studied this question.
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