Synthesis of Dibenzo[ a , e ]cyclooctatetraenes Enabled by a Palladium-Catalyzed Cross-Coupling Reaction

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Herein, we report a palladium-catalyzed cross-coupling reaction of sulfonylhydrazones with aryl or alkenyl halides, affording a diverse array of substituted dibenzo[ a, e ]cyclooctatetraenes featuring planar chirality. Substituents can be efficiently installed onto both aryl and alkene moieties. Preliminary asymmetric investigations have also been conducted, presenting a promising strategy for the enantioselective synthesis of cyclooctatetraene, an underexplored chiral diene ligand.