Why the study?
Do equal doses of inhaled fenoterol, isoprenaline, and salbutamol have different cardiovascular and hypokalaemic effects in healthy male volunteers?
Do equal doses of inhaled fenoterol, isoprenaline, and salbutamol have different cardiovascular and hypokalaemic effects in healthy male volunteers?
Inhaled fenoterol induces significantly greater chronotropic, electrocardiographic, and hypokalaemic effects compared to equal doses of isoprenaline or salbutamol in healthy volunteers.
Fenoterol's greater adverse effects warrant caution with repeated dosing; challenges beta-agonist equivalence on cardiovascular and electrolyte safety.
The cardiovascular and hypokalaemic effects of equal doses of inhaled fenoterol, isoprenaline and salbutamol were compared in eight healthy male volunteers, in a double blind, placebo controlled study. Increasing doses of 400, 600, and 800 micrograms were given from a metered dose inhaler at 15 minute intervals, followed by measurements of heart rate, blood pressure, total electromechanical systole (as a measure of inotropic response), QTc interval, and plasma potassium concentration. After repeated inhalation, fenoterol resulted in significantly greater chronotropic, electrocardiographic, and hypokalaemic effects than either isoprenaline or salbutamol. The maximum inotropic effect of fenoterol was similar to that of isoprenaline.
No takes yet. Share an insight, caveat, or question.
Crane et al. (1989) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: