Why the study?
Do equal doses of nebulised fenoterol, salbutamol, and terbutaline have different cardiovascular effects in healthy individuals?
Do equal doses of nebulised fenoterol, salbutamol, and terbutaline have different cardiovascular effects in healthy individuals?
Nebulised fenoterol produces greater chronotropic and inotropic cardiovascular effects compared to equal doses of salbutamol or terbutaline in healthy individuals.
Answers are grounded in this paper and cite their sources.
Fenoterol may warrant avoidance in patients with arrhythmia risk; confirms differential cardiovascular effects among nebulised beta-agonists.
The cardiovascular effects of equal doses (5 mg) of nebulised fenoterol, salbutamol and terbutaline were compared in 12 healthy individuals in a double-blind, placebo-controlled study. Measurements of heart rate, blood pressure, systolic time intervals, QTc interval and T-wave amplitude were made at baseline and at 15, 30, 45, 60 and 90 minutes after nebulisation. Fenoterol caused significantly greater chronotropic electrocardiographic and inotropic effects than either salbutamol or terbutaline. The peak effects after terbutaline occurred later than those after fenoterol or salbutamol.
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Flatt et al. (1990) studied this question.
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