Key result
Terbutaline injection increases both RVEF and LVEF in patients with severe stable COPD.
Why the study?
Does terbutaline injection improve right and left ventricular ejection fractions in patients with severe stable COPD?
Does terbutaline injection improve right and left ventricular ejection fractions in patients with severe stable COPD?
Terbutaline injection acutely improves both right and left ventricular ejection fractions in patients with severe stable COPD, which may contribute to its clinical benefits.
Terbutaline was associated with biventricular EF gains in severe COPD; observational data leaves open need for randomized confirmation before practice change.
The effect of 0.25 mg of terbutaline sulfate, a beta 2-adrenergic agent, on the right and left ventricular ejection fractions (RVEF and LVEF, respectively) was studied in 30 patients with severe stable chronic obstructive pulmonary disease (COPD) with a mean forced expiratory volume in 1 s of 0.79 +/- 0.06 L. All bronchodilator therapy was withdrawn 48 hours before the study. The ECG-synchronized gated equilibrium radionuclide ventriculography showed decreased RVEF in 27 patients and LVEF in 16 patients. Both the RVEF and LVEF significantly increased after the terbutaline injection; this increase was noted both in patients with normal and decreased ejection fractions. We conclude that the increase in ejection fractions after terbutaline injection may contribute to the good clinical response to this drug seen in patients with severe stable COPD even though the bronchodilator effect may be minimal.
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Ettayapuram V. Sunderrajan (1983) studied Severe stable chronic obstructive pulmonary disease (COPD) (n=30). Terbutaline sulfate vs. Baseline was evaluated on Right and left ventricular ejection fractions (RVEF and LVEF). Terbutaline sulfate injection (0.25 mg) significantly increased both right and left ventricular ejection fractions in patients with severe stable COPD.
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