What question did this study set out to answer?

To examine in vivo temporal changes in bikunin mRNA expression in rat kidney and liver tissues during the induction of calcium oxalate nephrolithiasis.

May 1, 1999Journal of the American Society of Nephrology

Temporal Changes in mRNA Expression for Bikunin in the Kidneys of Rats during Calcium Oxalate Nephrolithiasis

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Authors

SIShizuka IidaKurume University APAmmon B. PeckUniversity of Florida JJJoanne Johnson-Tardieu

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Implication

Experimental study reveals temporal upregulation of renal bikunin mRNA in rats with calcium oxalate nephrolithiasis, indicating a localized protective gene response against stone formation.

Key Points

To examine in vivo temporal changes in bikunin mRNA expression in rat kidney and liver tissues during the induction of calcium oxalate nephrolithiasis.
Induced hyperoxaluria and calcium oxalate nephrolithiasis in rats using an ethylene glycol challenge, comparing them against normal control rats.
Developed and applied reverse transcription-quantitative competitive template-PCR to detect and quantify poly(A)+ bikunin mRNA in kidney and positive control liver tissues.
Renal bikunin mRNA expression exhibited significant temporal increases during calcium oxalate nephrolithiasis following ethylene glycol exposure.
Urinary excretion of bikunin-containing proteins increased concomitantly with renal mRNA expression.
Hepatic bikunin mRNA expression showed no significant difference between stone-forming rats and normal controls.

Cite This Study

Iida et al. (1999) studied this question.

synapsesocial.com/papers/6a828b97d8c35e1a1e239ba2 https://doi.org/10.1681/asn.v105986

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Implication

Experimental study reveals temporal upregulation of renal bikunin mRNA in rats with calcium oxalate nephrolithiasis, indicating a localized protective gene response against stone formation.

Temporal Changes in mRNA Expression for Bikunin in the Kidneys of Rats during Calcium Oxalate Nephrolithiasis

Discussion

Member takes

Implication

Key Points

Cite This Study

Temporal Changes in mRNA Expression for Bikunin in the Kidneys of Rats during Calcium Oxalate Nephrolithiasis

Discussion

Member takes

Implication

Key Points

Cite This Study

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