Cimetidine and metoclopramide in oesophageal reflux disease.

Cimetidine and metoclopramide in oesophageal reflux diseaseAlthough cimetidine is effective in oesophageal reflux disease,' it is not as consistently useful as in peptic ulceration.Metoclopramide increases lower oesophageal sphincter pressure in normal subjects2 and patients with reflux: and speeds gastric emptying.4These properties together with the acid lowering effect of cimetidine appeared to provide a sound rationale for combination therapy. 3McCallum RW, Kline MM, Curry N, Sturdevant RAL.Comparative efforts of metoclopramide and bethanechol on lower esophageal sphinc- ter pressure in reflux patients.