A case of primary lung adenocarcinoma with mixed subtypes, predominantly of clear cell adenocarcinoma-Cytological and histopathological examination-

Chisa TACHIBANA; Hideaki Enzan; Akira Yamamoto; Masayuki Ishida; Makoto Toi; M. Hiroi

doi:10.5795/jjscc.49.262

January 1, 2010日本臨床細胞学会雑誌Open Access

A case of primary lung adenocarcinoma with mixed subtypes, predominantly of clear cell adenocarcinoma-Cytological and histopathological examination-

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Key Points

To evaluate the cytological and histopathological features and diagnostic challenges of rare primary mixed-subtype lung adenocarcinoma predominantly comprising clear cell adenocarcinoma.
Evaluated an 80-year-old female presenting with persistent cough and a 2.5 cm right upper lobe nodule on chest radiography and computed tomography.
Conducted pre-operative diagnostic bronchoscopy with bronchial brushing cytology and transbronchial lung biopsy, followed by right upper lobectomy and histopathological examination of the resected tumor.
Pre-operative bronchial brushing cytology and transbronchial lung biopsy revealed poorly differentiated adenocarcinoma with bare nuclei and disrupted cell membranes.
Post-operative histopathological examination of the resected mass demonstrated that over 90% of the tumor consisted of clear cell adenocarcinoma, with clearing caused by hydropic degeneration.

Implication

Case report demonstrates diagnostic discrepancies between biopsy and resected specimens in clear cell lung adenocarcinoma, highlighting sampling artifacts from cellular hydropic degeneration.

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TACHIBANA et al. (2010) studied this question.

synapsesocial.com/papers/6a828c86abc87fc4bf1e0c35 https://doi.org/10.5795/jjscc.49.262

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A case of primary lung adenocarcinoma with mixed subtypes, predominantly of clear cell adenocarcinoma-Cytological and histopathological examination-

Key Points

Implication

Discussion

Cite This Study

A case of primary lung adenocarcinoma with mixed subtypes, predominantly of clear cell adenocarcinoma-Cytological and histopathological examination-

Key Points

Implication

Discussion

Cite This Study

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