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January 1, 2012Journal of Cardiovascular Magnetic ResonanceOpen Access

MultiContrast Delayed Enhancement (MCODE) improves detection of subendocardial myocardial infarction by late gadolinium enhancement cardiovascular magnetic resonance: a clinical validation study

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Why the study?

Does MCODE improve the detection of myocardial infarction compared to standard LGE imaging in patients referred for CMR?

Population

73 patients referred for cardiovascular magnetic resonance including a late gadolinium enhancement study. 46…

Comparison

MultiContrast Delayed Enhancement CMR imaging vs Standard phase sensitive inversion recovery LGE…

Design

Cross-sectional, Images at each of multiple time points were read on separate…

Authors

WBW. Patricia BandettiniPKPeter KellmanCMChristine Mancini

Discussion

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Overview

May enhance subendocardial MI detection on CMR; leaves open its role pending prospective validation.

Structured PICO

Does MCODE improve the detection of myocardial infarction compared to standard LGE imaging in patients referred for CMR?

P
Population
73 patients referred for cardiovascular magnetic resonance (CMR) including a late gadolinium enhancement (LGE) study. 46 patients had a final diagnosis of MI (30 subendocardial and 16 transmural).
I
Intervention
MultiContrast Delayed Enhancement (MCODE) CMR imaging
C
Comparator
Standard phase sensitive inversion recovery (PSIR) LGE imaging
O
Outcome
Detection of myocardial infarction (presence, transmural vs subendocardial, and extent on a sector-by-sector basis)surrogate

MCODE improves the detection of subendocardial myocardial infarction compared to standard LGE imaging by providing simultaneous T1 and T2-weighted images to better differentiate blood pool from enhanced myocardium.

Cite This Study

Bandettini et al. (2012) studied this question.

synapsesocial.com/papers/6a828cae92c19701ea21dc1bhttps://doi.org/10.1186/1532-429x-14-83
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multicontrast delayed enhancement provides improved contrast between myocardial infarction and blood pool2005 · 51 citations
  2. 2Performance of Delayed-Enhancement Magnetic Resonance Imaging With Gadoversetamide Contrast for the Detection and Assessment of Myocardial Infarction2008 · 279 citations
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  4. 4The Use of Contrast-Enhanced Magnetic Resonance Imaging to Identify Reversible Myocardial Dysfunction2000 · 3,311 citations
  5. 5Myocardial Infarct: Depiction with Contrast-enhanced MR Imaging—Comparison of Gadopentetate and Gadobenate2005 · 44 citations