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October 7, 2005Journal of Magnetic Resonance ImagingOpen Access

Multicontrast delayed enhancement provides improved contrast between myocardial infarction and blood pool

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Key result

Multi-contrast delayed-enhancement imaging significantly improved MI-to-blood contrast-to-noise ratio compared to T1-weighted imaging (22.5 vs 2.9 for True FISP, P<0.001).

Why the study?

Does multi-contrast delayed-enhancement (MCODE) imaging improve contrast between myocardial infarction and blood pool compared to T1-weighted imaging?

Population

n=11 subjects with myocardial infarction

Comparison

Multi-contrast delayed-enhancement imaging method vs T1-weighted image

Design

Other

Authors

PKPeter KellmanCardiac ImagingYCYiu‐Cho ChungSiemens (Singapore)OSOrlando P. SimonettiCardiac Imaging

Discussion

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Implication

May facilitate clearer MI-blood contrast on CMR; leaves open diagnostic accuracy and outcome impact pending validation.

Key Points

  • This research aims to develop a delayed-enhancement imaging technique to improve contrast between myocardial infarction and surrounding blood.
  • Developed a multi-contrast delayed-enhancement (MCODE) imaging method using both T1 and T2 weightings.
  • Utilized T2-weighted images to evaluate visual discrimination between myocardial infarction and blood pool in a sample of N=11.
  • Compared contrast-to-noise ratio (CNR) across T1- and T2-weighted images.
  • T2-weighted images showed a significantly higher CNR for MI-to-blood comparison (22.5±8.7) compared to T1-weighted (2.9±3.1), P<0.001.
  • For Turbo FLASH, T2-weighted images had improved CNR (19.4±10.8) versus T1-weighted images (3.9±2.3), P<0.001.
  • Proposed method enhances the detection and sizing of myocardial infarctions by providing clearer images.

Structured PICO

Does multi-contrast delayed-enhancement (MCODE) imaging improve contrast between myocardial infarction and blood pool compared to T1-weighted imaging?

P
Population
11 cases evaluated to compare T2-weighted and T1-weighted imaging for myocardial infarction.
I
Intervention
Multi-contrast delayed-enhancement (MCODE) imaging method (T2-weighted image)
C
Comparator
T1-weighted image
O
Outcome
Contrast-to-noise ratio (CNR) between myocardial infarction and blood poolsurrogate

Main Result

Absolute Event Rate: 22.5% vs 2.9%

p-value: p=<0.001

The MCODE imaging method significantly improves the ability to discriminate subendocardial MI by providing high contrast between blood and MI.

Cite This Study

Kellman et al. (2005) studied Myocardial infarction (n=11). Multi-contrast delayed-enhancement (MCODE) imaging vs. T1-weighted imaging was evaluated on MI-to-blood contrast-to-noise ratio (CNR) for True FISP (p=<0.001). Multi-contrast delayed-enhancement imaging significantly improved MI-to-blood contrast-to-noise ratio compared to T1-weighted imaging (22.5 vs 2.9 for True FISP, P<0.001).

synapsesocial.com/papers/6a614056ba6827eff93f3c2ehttps://doi.org/10.1002/jmri.20426
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