What question did this study set out to answer?

May 4, 2004CirculationOpen Access

Delayed Enhancement and T2-Weighted Cardiovascular Magnetic Resonance Imaging Differentiate Acute From Chronic Myocardial Infarction

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Why the study?

Does combining delayed enhancement and T2-weighted CMR accurately differentiate acute from chronic myocardial infarction in MI patients?

Population

73 patients with acute or chronic myocardial infarction, divided into Group A and Group B.

Comparison

Combined delayed enhancement and T2-weighted… vs Coronary angiography and/or ECG changes as…

Design

Cohort, Images examined visually by 2 blinded observers

Follow-up

3 months (for Group A)

Authors

HAHassan Abdel‐AtyRoyal Marsden NHS Foundation Trust AZAnja ZagrosekCardiac Imaging JSJeanette Schulz‐MengerCardiac Imaging

Discussion

Member takes

Implication

Supports combined T2/DE CMR differentiation of acute from chronic MI; leaves open prospective validation before practice change.

Key Points

This research aimed to evaluate the effectiveness of combining delayed enhancement and T2-weighted cardiovascular magnetic resonance imaging to differentiate acute and chronic myocardial infarction.
Seventy-three myocardial infarction patients were studied in two groups: 15 acute MI patients scanned at two time points, and 58 patients scanned once.
Quantitative and qualitative assessments of T2-weighted and DE images were performed to analyze signal changes and differentiate infarction types.
Coronary angiography and/or ECG changes were utilized as reference standards for infarct localization.
The contrast-to-noise ratio on T2-weighted images significantly decreased from 2.7±1.1 on day 1 to 0.1±1.2 after three months (P<0.0001).
No significant change in the contrast-to-noise ratio for DE images was observed (1.9±1.5 vs 1.3±1.0; P=NS).
The qualitative assessment identified a specificity of 96% for differentiating acute from chronic lesions.

Structured PICO

Does combining delayed enhancement and T2-weighted CMR accurately differentiate acute from chronic myocardial infarction in MI patients?

Population

73 patients with acute or chronic myocardial infarction (MI), divided into Group A (n=15 acute MI patients) and Group B (n=58 acute or chronic MI patients).

Intervention

Combined delayed enhancement (DE) and T2-weighted cardiovascular magnetic resonance (CMR) imaging on a 1.5-T system.

Comparator

Coronary angiography and/or ECG changes as reference standard, and comparison between acute (day 1) and chronic (3 months) phases.

Outcome

Differentiation of acute from chronic MI based on contrast-to-noise ratio changes and qualitative assessment of hyperintense areas.surrogate

Combining delayed enhancement and T2-weighted CMR accurately differentiates acute from chronic myocardial infarction by detecting infarct-related myocardial edema.

Cite This Study

Abdel‐Aty et al. (2004) studied this question.

synapsesocial.com/papers/69f69057e405cc4465bc2886 https://doi.org/10.1161/01.cir.0000127428.10985.c6

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Delayed Enhancement and T2-Weighted Cardiovascular Magnetic Resonance Imaging Differentiate Acute From Chronic Myocardial Infarction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Delayed Enhancement and T2-Weighted Cardiovascular Magnetic Resonance Imaging Differentiate Acute From Chronic Myocardial Infarction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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