Population
Recombinant NS5B enzyme of hepatitis C virus (HCV) and viral RNA templates
Design
Preclinical
Authors
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Demonstrates primer-independent full-length HCV RNA synthesis in vitro; leaves open utility for antiviral screening or clinical translation.
This study reports the first recombinant HCV RNA-dependent RNA polymerase capable of copying the full-length HCV RNA in a primer-independent manner, mimicking the functional viral enzyme.
Oh et al. (1999) studied this question.
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