What question did this study set out to answer?

To assess hepatic venous oxygen saturation and hepatic arteriovenous oxygen differences during exercise to determine splanchnic blood flow responses in patients with rheumatic heart disease.

July 1, 1955Journal of Clinical InvestigationOpen Access

Changes in the Oxygen Content of Hepatic Venous Blood During Exercise in Patients With Rheumatic Heart Disease

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Why the study?

Does leg exercise alter the oxygen saturation of hepatic venous blood in patients with rheumatic heart disease?

Population

Patients with rheumatic heart disease

Comparison

Leg exercise vs Rest (baseline)

Authors

JBJ. M. BishopUniversity of London KDK. W. DonaldGriffith University OWO. L. WadeMadison Group (United States)

Discussion

Member takes

Implication

Provides preliminary physiological data on splanchnic flow during exercise in rheumatic heart disease; leaves open questions on clinical relevance pending larger studies.

Key Points

To assess hepatic venous oxygen saturation and hepatic arteriovenous oxygen differences during exercise to determine splanchnic blood flow responses in patients with rheumatic heart disease.
Obtained serial blood samples from the pulmonary artery and hepatic veins via intravenous catheterization at rest, during leg exercise, and throughout recovery.
Measured blood oxygen saturation to compute systemic and hepatic arteriovenous oxygen content differences, inferring alterations in splanchnic perfusion.
Mixed venous blood oxygen saturation dropped below 10 percent during exercise in several patients, producing abnormally large systemic arteriovenous oxygen differences.
Exercise induced marked increases in hepatic arteriovenous oxygen differences, indicating a substantial compensatory reduction in splanchnic blood flow.

Structured PICO

Does leg exercise alter the oxygen saturation of hepatic venous blood in patients with rheumatic heart disease?

Population

Patients with rheumatic heart disease

Intervention

Leg exercise

Comparator

Rest (baseline)

Outcome

Changes in oxygen saturation of hepatic venous blood and hepatic arterio-venous oxygen content differencesurrogate

This physiological study investigates changes in splanchnic blood flow during exercise in patients with rheumatic heart disease by measuring hepatic venous oxygen saturation.

Cite This Study

Bishop et al. (1955) studied this question.

synapsesocial.com/papers/6a828d92c40fc255ce133197 https://doi.org/10.1172/jci103161

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Implication

Provides preliminary physiological data on splanchnic flow during exercise in rheumatic heart disease; leaves open questions on clinical relevance pending larger studies.

Changes in the Oxygen Content of Hepatic Venous Blood During Exercise in Patients With Rheumatic Heart Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Changes in the Oxygen Content of Hepatic Venous Blood During Exercise in Patients With Rheumatic Heart Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider