Concomitant Acceleration of the Activation and Inactivation Kinetics of the Human Delayed Rectifier K+ Channel (Kv1.1) by Ca2+-independent Phospholipase A2

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Population

Sf9 cells expressing the human recombinant delayed rectifier K+ channel Kv1.1

Comparison

Intracellular administration of 40-kDa… vs Baseline/untreated state

Design

Preclinical

Authors

Discussion

iPLA2 alters human Kv1.1 gating in vitro; leaves open physiologic roles in native excitability.

Population

Sf9 cells expressing the human recombinant delayed rectifier K+ channel Kv1.1

Intervention

Intracellular administration of 40-kDa Ca(2+)-independent phospholipase A2 (PLA2) or exogenous arachidonic acid

Comparator

Baseline/untreated state

Outcome

Rate of activation and inactivation of the macroscopic K+ currentsurrogate

Arachidonic acid and Ca2+-independent phospholipase A2 directly modulate the electrophysiologic function of the human Kv1.1 potassium channel.

Gubitosi‐Klug et al. (1995) studied this question.

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