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July 28, 1997The Journal of Cell BiologyOpen Access

Myosin II Is Involved in the Production of Constitutive Transport Vesicles from the TGN

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Population

Polarized MDCK cells (in vitro assay)

Comparison

Depletion of p200/myosin II, addition of… vs Control levels

Design

Preclinical

Authors

AMAnne MüschAlbert Einstein College of MedicineDCDavid CohenCentre National de la Recherche ScientifiqueEREnrique Rodríguez-BoulanCornell University

Discussion

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Implication

No immediate clinical implications from cell models; leaves open myosin II relevance to mammalian secretion or disease.

Structured PICO

P
Population
Polarized MDCK cells (in vitro assay)
I
Intervention
Depletion of p200/myosin II, addition of purified nonmuscle myosin II, or inhibitors of actin-stimulated ATPase activity of myosin
C
Comparator
Control levels
O
Outcome
Release of basolateral transport vesicles carrying vesicular stomatitis virus G protein (VSVG) from the TGNsurrogate

This study provides functional evidence that nonmuscle myosin II is involved in the production of transport vesicles from the trans-Golgi network.

Cite This Study

Müsch et al. (1997) studied this question.

synapsesocial.com/papers/6a828f45040bdabcf346f367https://doi.org/10.1083/jcb.138.2.291
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Movement of myosin fragments in vitro: Domains involved in force production1987 · 90 citations
  2. 2Coat Proteins and Vesicle Budding1996 · 953 citations
  3. 3The in Vitro Generation of Post-Golgi Vesicles Carrying Viral Envelope Glycoproteins Requires an ARF-like GTP-binding Protein and a Protein Kinase C Associated with the Golgi Apparatus1996 · 59 citations
  4. 4Distinct coated vesicles labeled for p200 bud from trans-Golgi network membranes.1995 · 67 citations
  5. 5A novel adaptor-related protein complex.1996 · 244 citations