Key result
Spir actin nucleators and MyoVa colocalize at Rab8a vesicles, suggesting that Rab8/MyoV and possibly other MyoV transport processes recruit Spir actin filament nucleation function.
Key points are not available for this paper at this time.
Answers are grounded in this paper and cite their sources.
Direct Spir-MyoV complex coordinates vesicle actin tracks beyond Rab11 oocytes; leaves open roles across Rab GTPases and clinical translation.
Spir actin nucleators and myosin V motor proteins were recently discovered to coexist in a protein complex. The direct interaction allows the coordinated activation of actin motor proteins and actin filament track generation at vesicle membranes. By now the cooperation of myosin V (MyoV) motors and Spir actin nucleation function has only been shown in the exocytic transport of Rab11 vesicles in metaphase mouse oocytes. Next to Rab11, myosin V motors however interact with a variety of Rab GTPases including Rab3, Rab8 and Rab10. As a common theme most of the MyoV interacting Rab GTPases function at different steps along the exocytic transport routes. We here summarize the different transport functions of class V myosins and provide as proof of principle data showing a colocalization of Spir actin nucleators and MyoVa at Rab8a vesicles. This suggests that besides Rab11/MyoV transport also the Rab8/MyoV and possibly other MyoV transport processes recruit Spir actin filament nucleation function.
No takes yet. Share an insight, caveat, or question.
Welz et al. (2017) reported a review. Spir actin nucleators and MyoVa colocalize at Rab8a vesicles, suggesting that Rab8/MyoV and possibly other MyoV transport processes recruit Spir actin filament nucleation function.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: