Key result
Crystal structures reveal that the myosin V globular tail domain interacts directly with a Spir sequence motif and Rab11, forming a ternary complex that coordinates F-actin nucleation and vesicle transport.
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Advances membrane cytoskeletal coordination models; leaves open roles in cardiovascular vesicle trafficking and cell motility.
Pylypenko et al. (2016) studied this question. Crystal structures reveal that the myosin V globular tail domain interacts directly with a Spir sequence motif and Rab11, forming a ternary complex that coordinates F-actin nucleation and vesicle transport.
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