This review outlines surgical and echocardiographic techniques for assessing infarct size and area at risk in murine models of myocardial infarction.
Supports standardized infarct assessment in murine MI models; leaves open validation across labs and clinical translation.
Genetically modified mice are used extensively in models of ischemia reperfusion (I/R) and nonreperfused myocardial infarction (MI) to gain insights into pathways involved in these pathologies. Echocardiography is an ideal noninvasive tool to serially monitor the cardiac murine phenotype. The present review details the surgical aspects of I/R and MI models and the measurement of MI size by pathology techniques and the input of echocardiographic techniques including the extent of wall motion abnormality and of perfusion defects using myocardial contrast echocardiography in the assessment of murine area at risk and MI size.
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Scherrer‐Crosbie et al. (2006) studied this question.
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