The Role of Macrophages in Nonischemic Heart Failure
Population
Mouse model of transverse aortic constriction (pressure overload)
Comparison
CCR2 antagonist RS-504393 or anti-CCR2… vs Immunoglobulin G-treated animals
Design
Editorial
Follow-up
up to 4 weeks
Authors
Discussion
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Member takes
Implication
This editorial highlights evidence that chemokine-driven, macrophage-mediated inflammation plays a critical role in the pathogenesis of pressure overload-induced heart failure.
Structured PICO
P
Population
Mouse model of transverse aortic constriction (pressure overload)
I
Intervention
CCR2 antagonist RS-504393 or anti-CCR2 monoclonal antibody MC21
C
Comparator
Immunoglobulin G-treated animals
O
Outcome
Myocardial infiltration with CCR2+ macrophages, left ventricular hypertrophy, systolic dysfunction, and cardiac interstitial fibrosissurrogate
This editorial highlights evidence that chemokine-driven, macrophage-mediated inflammation plays a critical role in the pathogenesis of pressure overload-induced heart failure.
Cite This Study
Chen et al. (2018) studied this question.