Why the study?
Whether cardiac resident immune cells influence the early phase of hypertrophy development during cardiac pressure overload has not been established.
Does depletion of cardiac resident macrophages worsen fibrosis and angiogenesis in response to cardiac pressure overload in mice?
Population
Mice undergoing TAC or sham, including CCR2 knockout mice
Comparison
Preferential depletion of resident macrophages vs control
Design
Preclinical animal study
Follow-up
6 weeks after TAC
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Resident macrophage depletion worsens remodeling in pressure-overload mice; leaves open therapeutic targeting in human HF.
Does depletion of cardiac resident macrophages worsen fibrosis and angiogenesis in response to cardiac pressure overload in mice?
Cardiac resident macrophages are crucial for stimulating angiogenesis and inhibiting fibrosis during the early response to pressure overload, preventing progression to heart failure.
A 2021 study studied this question.
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