Why the study?
Does applied positive airway pressure (PEEP) affect pericardial pressure in dogs with normal lungs or acute lung injury?
Population
Closed-chest, anesthetized dogs with normal lungs and animals with oleic acid-induced lung injury
Comparison
Applied positive airway pressure up to 15 cm… vs Baseline volume condition vs volume loading…
Design
Preclinical
Authors
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Volume status may modulate PEEP effects on pericardial pressure; animal data leave open human translation.
Does applied positive airway pressure (PEEP) affect pericardial pressure in dogs with normal lungs or acute lung injury?
Transmission of airway pressure to the pericardial surface is independent of acute lung injury, and changes in pericardial pressure in response to PEEP reflect both airway pressure transmission and PEEP-related changes in cardiac volume and compliance.
Cabrera et al. (1989) studied this question.
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