What question did this study set out to answer?

Determine plasma levels of immunoreactive matrix metalloproteinase-9 (MMP-9) in patients with hepatocellular carcinoma and analyze their relationship with vascular invasion and other clinical features.

November 1, 1996Hepatology

Elevated plasma levels of matrix metalloproteinase-9 (92-kd type IV collagenase/gelatinase B) in hepatocellular carcinoma

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Authors

AHAkira HayasakaOsaka Kyoiku University

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Implication

Comparative study reveals elevated plasma matrix metalloproteinase-9 in hepatocellular carcinoma, indicating potential utility for detecting vascular invasion.

Key Points

Determine plasma levels of immunoreactive matrix metalloproteinase-9 (MMP-9) in patients with hepatocellular carcinoma and analyze their relationship with vascular invasion and other clinical features.
Measured plasma MMP-9 concentrations using a one-step sandwich enzyme immunoassay in 100 patients with hepatocellular carcinoma (HCC), 21 with chronic hepatitis, 24 with liver cirrhosis, and 138 healthy controls.
Evaluated diagnostic performance via receiver operating characteristic analysis and assessed correlations with tumor size, volume, number, serum alpha-fetoprotein, and portal venous invasion.
Median plasma MMP-9 was 62 ng/mL in HCC, significantly higher than in healthy controls (36 ng/mL, P < 0.0000001), chronic hepatitis (28 ng/mL, P = 0.0000003), and liver cirrhosis (35 ng/mL, P = 0.00205).
A cutoff of 60 ng/mL yielded 53% sensitivity and 89% specificity for distinguishing HCC from chronic hepatitis and liver cirrhosis.
MMP-9 levels were significantly elevated in HCC patients with macroscopic portal venous invasion compared to those without invasion (median 79 vs. 44 ng/mL, P = 0.00726), with no correlation to tumor size, number, or alpha-fetoprotein.

Cite This Study

Akira Hayasaka (1996) studied this question.

synapsesocial.com/papers/6a82929323a6926b671e0d63 https://doi.org/10.1053/jhep.1996.v24.pm0008903375

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Implication

Comparative study reveals elevated plasma matrix metalloproteinase-9 in hepatocellular carcinoma, indicating potential utility for detecting vascular invasion.

Elevated plasma levels of matrix metalloproteinase-9 (92-kd type IV collagenase/gelatinase B) in hepatocellular carcinoma

Discussion

Member takes

Implication

Key Points

Cite This Study

Elevated plasma levels of matrix metalloproteinase-9 (92-kd type IV collagenase/gelatinase B) in hepatocellular carcinoma

Discussion

Member takes

Implication

Key Points

Cite This Study

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