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December 5, 2007Proceedings of the National Academy of SciencesOpen Access

Loss of skeletal muscle strength by ablation of the sarcoplasmic reticulum protein JP45

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Population

young mice

Design

Preclinical

Authors

ODOsvaldo DelbonoJXJinyu XiaSTSusan Treves

Discussion

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Overview

Does not inform human muscle weakness management; leaves open JP45 as a target in excitation-contraction research.

Structured PICO

P
Population
young mice
I
Intervention
deletion of the gene encoding the sarcoplasmic reticulum protein JP45 (JP45 knockout)
O
Outcome
muscle strength and functional expression of the voltage-dependent Ca(2+) channel Ca(v)1.1surrogate

JP45 is identified as a molecule involved in the development or maintenance of skeletal muscle strength through its effect on Ca(v)1.1 expression.

Cite This Study

Delbono et al. (2007) studied this question.

synapsesocial.com/papers/6a829aa25b7acbbacb8d5eb2https://doi.org/10.1073/pnas.0707389104
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Skeletal muscle weakness in old age1994 · 363 citations
  2. 2The Novel Skeletal Muscle Sarcoplasmic Reticulum JP-45 Protein2003 · 42 citations
  3. 3Identification of a novel 45 kDa protein (JP-45) from rabbit sarcoplasmic-reticulum junctional-face membrane2000 · 33 citations
  4. 4Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion2004 · 125 citations
  5. 5STRUCTURE AND FUNCTION OF VOLTAGE-GATED ION CHANNELS1995 · 954 citations