Why the study?
Does maintaining basal angiotensin II levels prevent the excretion of an acute sodium load in healthy subjects?
Population
8 healthy subjects given an acute Na+ load (2 liters 0.9% saline)
Comparison
Angiotensin II infusion to maintain plasma ANG… vs Placebo
Design
Other, placebo-controlled
Follow-up
5 hours
Authors
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Maintaining basal ANG II prevents acute natriuresis; confirms its suppression as a key mechanism independent of aldosterone.
Does maintaining basal angiotensin II levels prevent the excretion of an acute sodium load in healthy subjects?
Suppression of angiotensin II is a major physiological mechanism permitting acute sodium excretion following an intravenous sodium load, independent of its effects on aldosterone.
Singer et al. (1994) studied this question.
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