Key result
Elevated hsCRP and oxidized LDL levels are linked to increased cardiovascular disease risk.
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C-reactive protein (CRP) is a marker of inflammation. Atherosclerosis is now recognized as inflammatory disease, and it seems that CRP directly contributes to atherogenesis. Oxidation of low-density lipoprotein (LDL) molecule increases the uptake of lipid products by macrophages leading to cholesterol accumulation and subsequent foam cell formation. The elevated levels of high sensitivity CRP (hsCRP) and oxidized LDL (OxLDL) in the blood were found to be associated with cardiovascular diseases (CVD). In this review, we highlighted the evidence that CRP and OxLDL are involved in interrelated (patho) physiological pathways. The findings on association between hsCRP and OxLDL in the clinical setting will be also summarized.
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Obradović et al. (2014) conducted a review in Cardiovascular diseases and atherosclerosis. C-reactive protein (CRP) and oxidized LDL (OxLDL) was evaluated on Association between hsCRP and OxLDL in pathophysiological pathways and clinical settings. C-reactive protein and oxidized LDL are involved in interrelated pathophysiological pathways, with elevated blood levels of both markers associated with cardiovascular diseases.
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